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AI解码人类基因关键DNA“起始子”序列特征_我的网站

一 |     AKRON, Ohio -- The eight Ohio police officers who fired scores of shots that killed Jayland Walker, a 25-year-old Black man, after a car and foot chase last year are back on active duty, officials said.Akron Capt. Michael Miller, in a statement, cited a state investigation and an Ohio grand jury's decision against indicting any officers in the June 2022 shooting death of Walker. As a result, he said, "all eight officers are back on full-time, active duty.” Miller also said the department’s internal probe of the shooting is going through a final legal review and is expected to be released at the end of November.Walker family attorney Bobby DiCello told WKYC-TV that the family is “saddened by the way in which they continue to be ignored” by the city of Akron, whose leaders, he said, have “never once reached out to discuss the employment of the eight officers or explain why the officers are being reinstated.” Police said officers tried to pull over Walker's car for minor equipment violations and that he failed to stop and then fired a shot from the vehicle 40 seconds into the pursuit. Ohio Attorney General Dave Yost said the state’s investigation found that Walker then jumped out of his still-moving car, ran from police and ignored commands to stop and show his hands. Some of the officers first used Tasers to try and stop Walker, but he reached toward his waistband and raised a hand as officers were chasing, Yost said. The officers, not knowing that Walker had left his gun in the car, believed he was going to fire again, Yost said. In April, a Summit County grand jury declined to indict the eight officers, who fired a total of 94 shots in just under seven seconds, hitting Walker 46 times. The officers, whose identities haven’t been released, were put on leave following the shooting and then reinstated to desk duty in October 2022.Months of protests followed the shooting, and the family has filed a $45 million lawsuit against the city and the department. Akron's police chief, Steve Mylett, announced last month that he will retire at the end of the year.At the time of the shooting, Walker was grieving his fiancee’s recent death, and his family and Anthony Pierson, an assistant state attorney general, said his actions that night were out of character. “By all accounts he was a good person, a good man,” Pierson said.Attorneys for the eight officers released a statement earlier calling the shooting a tragedy for the entire community, including Walker’s family and all of the officers who were involved. “A split-second decision to use lethal force is one that every police officer hopes he or she will never be forced to make,” the statement said.。

二 |     研究人员利用人工智能解码基因激活中的关键DNA序列。

三 | 图片来源：美国加州大学圣迭戈分校官网　　美国加州大学圣迭戈分校研究人员利用高通量DNA测序和人工智能技术，解码了人类基因中一段名为“起始子”的关键DNA序列特征。这项成果为解析基因表达调控规律和预测DNA突变影响提供了新工具。相关论文发表于最新一期《基因与发育》杂志。　　人体不同类型的细胞虽然拥有基本相同的DNA，但由于被激活的基因不同，最终能够形成不同的细胞类型，并执行各自特定的功能。DNA中的一些特殊片段负责精细调控基因表达，使细胞产生酶、激素、蛋白质以及维持细胞结构和功能所需的其他重要成分。

四 | 如果这些基因没有被正确激活，细胞可能无法正常发挥功能，并可能引发包括癌症在内的多种疾病。　　为了进一步弄清DNA中哪些序列负责启动基因表达，研究人员将目光投向了“起始子”。这是基因表达过程中的一个重要DNA区域，是基因编码的信息开始被表达，进而产生具有功能产物的关键区域。

五 | 　　研究人员利用高通量DNA测序技术，检测了约50万个不同“起始子”序列的基因表达活性。随后，他们将这些实验数据用于训练机器学习模型，使AI能够识别“起始子”特有的DNA序列模式。

六 | 　　利用训练出的模型，研究人员进一步在人体基因中搜索“起始子”的特征序列，发现约60%的人类基因含有“起始子”。他们表示，这些AI模型首次能够预测人类基因中是否存在“起始子”，并解码其DNA碱基序列模式。

七 | 相关数据和模型还可用于预测“起始子”相关DNA突变的影响，以及设计具有特定功能的合成启动子，即能够调控基因开启和关闭的DNA序列。　　研究人员表示，人类每个细胞中都包含约60亿个DNA碱基，其中蕴含着决定基因何时、何地，以及以多大程度表达的复杂“密码”。此次建立的“起始子”AI模型只是解析这一基因表达“密码”的一小部分，希望未来进一步扩大模型范围，以更加全面地解析人类基因表达调控规律。（记者张佳欣）。

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Published on:16:00:22